Transdermal nitroglycerin pad

摘要

The present invention provides a trans-dermal delivery pad for nitroglycerin administration, specifically a microsealed, trans-dermal nitroglycerin pad having a backing which is impervious to nitroglycerin absorption and transport and a silicon matrix affixed thereto, said silicone polymer matrix being of cross-linked silicone rubber having from about 10 to 200 micron microsealed compartments being formed by in situ cross-linking of the silicone rubber after it is mixed with a hydrophilic solvent system containing the nitroglycerin and a hydrophobic solvent which enhances nitroglycerin dispersion and transport.