发明名称 |
Process for the preparation of 4-[2-(dimethylamino)-ethoxy]2-methyl-5-(1-methylethyl)-phenol esters and their salts |
摘要 |
This invention relates to a process for the preparation of 4-[2-(dimethylamino)-ethoxy]-2-methyl-5-(1-methylethyl)-phenol esters (I) and their salts with organic and inorganic acids comprising the reaction of thymol with a salt of an 1-halo-dimethylaminoethane to obtain ethylamine-N,N-dimethyl-2-(thymyloxy) (II), the subsequent reaction of (II) with an acylating agent according to the Friedel and Kraft reaction to obtain 4-[2-(dimethylamino)-ethoxy]-2-methyl-5-(1-methylethyl)-1-acyl-benzene (III) and the oxidation of (III) to obtain the products (I) which, if desired, may be transformed in their salts with organic or inorganic acids. This process allows to obtain the products (I) in high quality and quantity without isolating any intermediate product.
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申请公布号 |
US4336396(A) |
申请公布日期 |
1982.06.22 |
申请号 |
US19800212796 |
申请日期 |
1980.12.04 |
申请人 |
BLASINACHIM S.P.A. |
发明人 |
GIORDANO, CLAUDIO;BELLI, ALDO |
分类号 |
A61K31/215;C07C;C07C67/42;(IPC1-7):C07C79/46 |
主分类号 |
A61K31/215 |
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代理人 |
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主权项 |
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地址 |
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