发明名称 |
Process for the preparation of 7-(D(-)-alpha-amino-p-hydroxyphenylacetamido)desacetoxycephalosporanic acid |
摘要 |
There is described a process for the preparation of 7-(D(-)-alpha-amino-p-hydroxyphenylacetamido)desacetoxycephalosporanic acid in which a D(-)-p-hydroxy-N-(1-alcoxycarbonyl-2-propenyl)-alpha-aminophenylacetic acid salt is reacted with trimethylsilyl-2-oxazolidinone. The resulting reaction product is reacted in turn with an acyl chloride or an alkyl chloroformate to give a mixed anhydride which is reacted with a solution of 7-aminodesacetoxycephalosporanic acid prepared by silylation, in an anhydrous organic solvent, with trimethylsilyl-2-oxazolidinone.
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申请公布号 |
US4336376(A) |
申请公布日期 |
1982.06.22 |
申请号 |
US19810234896 |
申请日期 |
1981.02.17 |
申请人 |
GEMA, S.A. |
发明人 |
COLL, ANTONIO L. P.;MESEGUER, JOSE D.;BIANCHINI, ASUNCION E.;PITARCH, ESTEVE S. |
分类号 |
A61K31/545;C07D;C07D501/04;C07D501/06;C07D501/22;(IPC1-7):C07D501/04 |
主分类号 |
A61K31/545 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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