| 摘要 |
PCT No. PCT/CH80/00037 Sec. 371 Date Nov. 14, 1980 Sec. 102(e) Date Nov. 13, 1980 PCT Filed Mar. 14, 1980 PCT Pub. No. WO80/01914 PCT Pub. Date Sep. 18, 1980. The invention relates to cyano-urea and cyano-thiourea derivatives characterized by structures of formulas (a),(b),(c) and (d): <IMAGE> (a) <IMAGE> (b) <IMAGE> (c) <IMAGE> (d) in which R is 2-mercapto-ethyl radical or 2-((4-methyl-5-imidazolyl) thiomethyl) ethyl radical. The invention relates to the manufacture of cyano-ureas and cyano-thioureas. The compounds of invention: N-2-((4-methyl-5-imidazolyl)thiomethyl) ethyl-N'-imino-cyano-urea,N-2-((4-methyl-5-imidazolyl)thiomethyl) ethyl N'-imino-cyano-thiourea, as well as their carbonyl and thio-carbonyl tautomers are histamine antagonists in the H2 receptors which inhibit the secretion of gastric acid. They can be used therapeutically for the treatment of gastric and duodenal ulcers.
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