| 摘要 |
The present invention is directed to a process for producing 2-amino-2-arylacetonitriles of general formula I: <IMAGE> wherein R and R1 independently represent hydrogen, hydroxy, hydroxy(C1-C4)alkyl, (C1-C4)alkoxy, (C1-C6)alkyl, 2-furyl, 2-thienyl, 4-pyridinyl, 1-pyrrolydinyl, 1-piperidinyl, 4-morpholinyl, 1-piperazinyl, 4-methyl-1-piperazinyl, 4-phenylpiperazinyl, or phenyl which can optionally be substituted with from 1 to 3 substituents independently selected from (C1-C4)alkyl and (C1-C4)alkoxy, or R and R1 independently represent a phenyl(C1-C4)alkyl or a phenyl(C1-C4)alkoxy group wherein the phenyl group can be either unsubstituted or substituted as above. An arylaldehyde derivative of formula II <IMAGE> is reacted with chloroform in base and in the presence of ammonia to give the 2-amino-2-arylacetonitrile derivative. |
