发明名称 1-[3-(3,4,5-Trimethoxyphenoxy)-2-hydroxy-propyl]-4-aryl-piperazine-derivatives having pharmaceutical activity
摘要 There are prepared compounds corresponding to the general formula <IMAGE> I in which R1 is a hydrogen atom, a C2 to C6-alkanoyl group, a C3 to C6-alkenoyl group, a C3 to C6-cycloalkyl carbonyl group, a benzoyl group, an alkoxybenzoyl group, a nicotinoyl group, a thienyl carbonyl group, a furyl carbonyl group, a phenylacetyl group or a C1 to C4-alkoxyphenyl acetyl group and R2 represents a phenyl, naphthyl or pyridyl group or such group substituted by the groups R3 and R4, the groups R3 and R4, which may be the same or different, each representing hydrogen, hydroxyl, fluorine, chlorine, bromine, a nitro group, a trifluoromethyl group, a C1 to C6-alkyl group, a C1 to C6-alkoxy group, a C1 to C6-alkyl thio group, a C1 to C6-alkyl sulphonyl group, a C2 to C6-alkanoyl group, an amino group, an acylamino group or an acyloxy group in which the acyl is of the type defined in respect to R1, and their salts. The compounds are pharmacodynamically active.
申请公布号 US4335126(A) 申请公布日期 1982.06.15
申请号 US19800193482 申请日期 1980.10.03
申请人 DEGUSSA AKTIENGESELLSCHAFT 发明人 KLEEMANN, AXEL;JAKOVLEV, VLADIMIR;THIEMER, KLAUS;ENGEL, JUERGEN
分类号 C07D295/092;(IPC1-7):A61K31/49;C07D295/08 主分类号 C07D295/092
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