| 摘要 |
The 2,6-dichlorphenyl-substituted amino-imidazole derivatives 1-(2 min ,6 min -dichlorphenyl)-2-amino-4-methyl-imidazole, 2-(2 min ,6 min -dichloroanilino)-4-methyl-imidazole, their non-toxic, pharmaceutically acceptable, acid addition salts and mixtures thereof, exhibit excellent anti-hypertensive and anti-ulcer activities which makes the derivatives particularly suitable for treatment of high blood pressure and gastric ulcers in mammals. The derivatives may be prepared in either of two processes. The first process involves the sequential reaction of a known starting material with ammonia and a halogenated acetone which may be followed by separation of the formed isomers. The second process involves the decarboxylation of the novel intermediates 4-[1-(2 min ,6 min -dichlorphenyl)-2-amino)]-imidazoleacetic acid or 4-[2-(2 min ,6 min -dichloranilino)]-imidazoleacetic acid or mixtures thereof. The derivatives are employed in an effective amount and are typically combined with a pharmaceutical carrier. Administration of the derivatives may be accomplished either orally or parenterally. |
