PROCESS FOR OBTAINING 6-AMINOPENICILLANIC ACID, 7-AMINOPENICILLANIC ACID AND DERIVATIVES THEREOF IN POSITION 3

摘要

A process for preparing 6-APA and 7-ACA and derivatives therefore is disclosed wherein a penicillin or cephalosporin substrate is reacted with a molar excess of an oxalyl halide of the formula halCOCOhal whereby the COOM group of the substrate, wherein M represents hydrogen, metal or ammonium cations, is transformed into the group COOCOCOhal.