| 摘要 |
<p>2-Substituted 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-one compounds having the general formula <IMAGE> in which R represents a branched or unbranched alkyl group having 1 to 17 carbon atoms inclusive, a phenyl group optionally substituted by one or two lower alkyl groups, lower alkyloxy groups or halogen atoms, a phenylalkyl group, a lower alkyloxy group or a group -NHR<1> in which R<1> represents hydrogen, a lower alkyl, phenyl or cyclohexyl group, and pharmaceutically acceptable acid addition salts of these compounds have an activity connected to the activity of gamma -aminobutyric acid (GABA) and are indicated for use in the treatment of diseases which are connected to the faulty function of the GABA system, such as epilepsy, Parkinsonism, schizophrenia, Huntington's chorea (hereditary progressive chronic chorea), diseases in which a faulty function of the pituitary hormone plays a role and cerebral arteriosclerosis. The compounds additionally exhibit potent analgesic and myotonic action. They are prepared by acylating compounds of the general formula <IMAGE> in which R<2> represents an amino-protective group which is easily removable after acylation without affecting the acylated hydroxyl group. The invention also relates to medicaments which contain a compound of the formula I as active substance.</p> |
