Prostacyclin analogs of the 1 series and related analogs.

摘要

Prostacyclines of formula: <CHEM> and -C(O)OH wherein R1 is hydrogen or hydroxy, R is C1 to C6 alkyl, or optionally substituted phenyl, wherein the substituents are selected from the group C1 to C4 alkyl, C1 to C4 alkoxy, halo and trifluoromethyl and R16 is C1 to C6 alkyl; C13-C14 is selected from tile group -CH=CH-(trans) and -CM2CH2-; and R2 is selected from the group <CHEM> wherein R6 is C3 to C5 alkyl; R7 is C2 to C4 alkyl; R10 is C1 to C4 alkyl; R11 is C3 to C7 alkyl; R17 is hydrogen, methyl or ethyl; the racemic mixture thereof; the mirror image thereof; and the pharmaceutically acceptable, non-toxic salts thereof; and their intermediates. These compounds are useful as bronchodilators and inflammatory mediator release inhibitors.