| 摘要 |
2-Aryl-1H-perimidin derivs. ≮I; R = Ia, Ib (R1 = -OC2F5,-CF3, -OCF3, -SCF3; position of these group are meta or para)≉, useful as immuno supressant, were prepd. by reacting 1, 8-diamino naphthalene (IV) and compd. (V; X = F, C1, Br, H). Thus, benzene 500 m1 soln. of 1, 8-diamino naphthalene 31.64 g and benzene 500 m1 soln. of p-trifluoromethylbenzoyl chloride 20.8 g were added in the benzene 500 m1 and then stirred for 30 min to give 2- (p-trifluoromethyl phenyl)-1H-perimidin hydrochloride 24.6 g (m.p. 210≦̸C).
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