| 摘要 |
Amino acid salts of glutathione are prepared by mixing glutathione and a basic amino acid having two amino groups and one carboxyl group in water or an aqueous solvent and isolating the formed salt. The preparations of the L-lysine and L-ornithine salts of the reduced form of glutathione, and of the mono- and di-L-ornithine salts of the oxidized form of glutathione are described. Other specified amino acids are e -aminocaproic acid, L-tryptophan and DL-citrulline.ALSO:Pharmaceutical compositions comprise glutathione, either in its reduced or oxidised form, and one or more compounds selected from basic amino acids having two amino groups and one carboxyl group, mineral acid salts of such basic amino acids, tryptophan, citrulline, and o -amino acids having 3 to 7 C atoms. Specified basic amino acids are ornithine and lysine. e -aminocaproic acid is exemplified as a o -amino acid. Either L or DL forms of the amino acids may be used. The compositions may be administered orally or parenterally. The invention also comprises salts of glutathione and a basic amino acid having two amino groups and one carboxyl group in suitable pharmaceutical forms, e.g. tablets, capsules, injectable preparations. The compositions may be used as growth stimulants for domestic animals as well as radiation protectants. |
