摘要 |
Title compds. I (R1 = optionally substituted lower alkyl, C3-6 cycloalkyl, phenyl; A = H), having cardiac-exciting effect, were prepd. Thus, 4, 4-dimethyl-7-amino-8-nitro-1, 3 (2H, 4H)-isoquinolinedione was treated with 2, 4-dimethoxybenzoyl-chloride and hydrogenated to give 74.7% I (R1 = 2, 4-(MeO) 2C6 H3), which, at 2 mg/kg i.v. in cats, caused a 49 mm Hg decrease in arterial blood pressure.
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