| 摘要 |
The invention concerns new topical anti-inflammatory 1-phenyl-2-aminoethanol derivatives of the general formula: R1xCH(OH)xCH2NHxCR2R3xA1xNH[COxYxNH]nxQ wherein R1 is a phenyl bearing specific combinations of (2-12C)alkanoyloxy,[(2-12C)alkanoyloxy]methyl,chloro and amino substituents, R2 and R3 are independently hydrogen or (1-4C)alkyl, A1 is a (1-4C)alkylene, Y is a (1-4C)alkylene optionally bearing a (1-4C)alkyl or benzyl, n is an integer from 1 to 4, and Q is an optionally substituted benzoyl, phenylacetyl, or phenoxyacetyl together with the acid-addition salts thereof; and the pharmaceutical compositions thereof, for use in the treatment of inflammatory skin diseases and conditions. The invention also concerns processes for the manufacture of derivatives of formula I. A representative compound of the invention is 1-[3,4-bis(pivaloyloxy)phenyl]-2-{2-[(N-benzoylglycyl)amino]-1,1-dimet hyl-ethylamino}ethanol. |
