N-Amino:acyl-indoline and tetra:hydro-isoquinoline carboxylic acid(s) - which are aminoacid analogues with hypotensive activity

摘要

N-(Aminoacyl)-indoline-or -tetrahydro-isoquinoline-carboxylic acids (I) and their salts are new. n is 0 or 1; A is a fused on benzene or cyclohexane ring; R1 and R2 (both of which are opt. substd.) are 1-6C alkyl or alkenyl, 5-7C cycloalkyl or cycloalkenyl, 7-12C cycloalkyalkyl, 6-10C aryl or partially hydrogenated aryl, 7-14C aralkyl, or a mono-or bicyclic heterocycle with 5-7 or 8-10 ring members of which 1 or 2 may be S and/or O and/or up to 4 may be N; and R3 is H, 1-6C alkyl, 2-6C alkenyl or 7-14C aralkyl. The new cpds. have long-lasting intensive hypotensive activity and can be used for treating hypertenorin due to various causes. Dosages are 20-200 mg. orally or 0.01-10 mg. i.v. or s.c. for admin.