发明名称 PROCESS FOR PREPARING 5-SUBSTITUTED 1,2-DIHYDRO-3H-PYRROLO/1,2-A/-PYRROL-1-CARBOXYLIC ACID DERIVATIVES FROM THE CORRESPONDING NITRILES
摘要 <p>Compounds of the formula: <CHEM> wherein Y is <CHEM> in which R is hydrogen, methyl, chloro or bromo, the R substitution being at the 3, 4 or 5 positions of the thiophene ring, R<1> is hydrogen, a lower alkyl group having 1 to 4 carbon atoms, a lower alkoxy group having from 1 to 4 carbon atoms, chloro, fluoro or bromo, the R<1> substitution being at the ortho, meta or para positions of the aroyl group, and R<2> is hydrogen or a lower alkyl group having from 1 to 4 carbon atoms. <??>These compounds are used as intermediates for the preparation of the corresponding 1-carboxylic acid compounds by hydrolysis, the latter compounds being pharmaceutically useful. </p>
申请公布号 HU178354(B) 申请公布日期 1982.04.28
申请号 HU1978SI01640 申请日期 1978.07.21
申请人 SYNTEX INC,US 发明人 VAN HORN,ALBERT,R.,US;GALLEGRA,PASQUALE,G.,US
分类号 A61K31/40;A61P25/04;A61P29/00;C07D207/32;C07D207/335;C07D207/337;C07D333/38;C07D487/04;(IPC1-7):07D487/04 主分类号 A61K31/40
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