发明名称 |
Piridoxine derivatives, a process for their preparation and related pharmaceutical compositions. |
摘要 |
<p>The esters of pyridoxine and of isopropylidene pyridoxine with 1-(p-chlorobenzoyl)-2-methyl-5-methoxy--indol-3-acetic acid and 5-(2,4-difluorophenyl)-salicylic acid are essentially endowed with the same activities of the corresponding acids and are less toxic and gastrolesive, whereby the therapeutical index is remarkably improved.</p><p>For the preparation of these compounds the chloride of the acid is reacted with isopropylidene pyridoxine, followed by a hydrolysis to obtain the corresponding pyridoxine derivative.</p> |
申请公布号 |
EP0050385(A1) |
申请公布日期 |
1982.04.28 |
申请号 |
EP19810201119 |
申请日期 |
1981.10.08 |
申请人 |
D AND D S.R.L. |
发明人 |
REINER, ALBERTO |
分类号 |
C07D213/66;A61K31/435;A61K31/44;A61K31/4415;A61K31/4418;A61K31/4427;A61K31/625;A61P25/04;A61P29/00;B01J31/02;C07B61/00;C07D209/28;C07D213/67;C07D401/12;C07D491/04;C07D491/056;(IPC1-7):07D213/67;07D491/04;07D401/12;61K31/44 |
主分类号 |
C07D213/66 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|