发明名称 Phosphonooxy- or glycosyloxy-substituted acrylophenones, compositions and uses thereof
摘要 Compounds of the formula: <IMAGE> wherein R1 is hydroxy, phosphonooxy, aminoglycosyloxy, acylaminoglycosyloxy, benzyloxycarbonyloxy, arylcarbonyloxy, trialkylammonio-acyloxy or furoyloxy; R2 and R3 each are lower alkoxy; and R4 is benzimidazolyl, furyl which is unsubstituted or substituted with lower alkyl, thienyl which is unsubstituted or substituted with lower alkyl, or phenyl which is substituted with lower alkyl, lower alkoxy, alkoxyalkoxy, alkylthio, alkylenedioxy, or acyloxy, with the proviso that when R1 is hydroxy, R4 is benzimidazolyl or phenyl which is substituted by acyloxy or alkoxyalkoxy, or pharmaceutically acceptable salts thereof useful as antiviral agents.
申请公布号 US4327088(A) 申请公布日期 1982.04.27
申请号 US19800148616 申请日期 1980.05.12
申请人 HOFFMANN-LA ROCHE INC. 发明人 SHINMA, NOBUO;UMEDA, ISAO;ISHITSUKA, HIDEO;SUHARA, YASUJI
分类号 C07C69/017;A61K31/12;A61K31/195;A61K31/215;A61K31/22;A61K31/34;A61K31/341;A61K31/70;A61K31/7028;A61K31/7034;A61P31/12;C07C45/00;C07C45/74;C07C49/84;C07C67/00;C07C69/96;C07C227/00;C07C227/12;C07C229/12;C07C313/00;C07C319/20;C07C323/22;C07D235/06;C07D235/12;C07D307/68;C07D333/22;C07F9/12;C07F9/38;C07F9/40;C07H15/203;C07H17/07;(IPC1-7):A61K31/66;A61K31/72;C07H15/20 主分类号 C07C69/017
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