发明名称 |
PRODUCTION OF ALDEHYDE-TREATED ALLERGEN-CONTAINING SUBSTANCES |
摘要 |
<p>This invention relates to an improved method of production of formaldehyde, and lower saturated aliphatic dialdehyde-treated allergens suitable for the immunotherapy (desensitization) of individuals suffering from allergies of the immediate type in a plurality of steps wherein said formaldehyde and/or said dialdehyde is utilized alone or in combination for the modification of allergen-containing materials. These lower saturated aliphatic mono- and dialdehyde treated allergencontaining materials are useful in ameliorating the symptoms of allergic (atopic) people. Also, they are able to induce formation of blocking antibody in mammals which cross-reacts with the native allergen-containing materials. Reactions with formaldehyde are carried out in a non-phenolic environment in a plurality of steps. The reaction involving combinations of aldehydes can be carried out in a single step.</p> |
申请公布号 |
CA1122525(A) |
申请公布日期 |
1982.04.27 |
申请号 |
CA19790336952 |
申请日期 |
1979.10.04 |
申请人 |
JOHNS HOPKINS UNIVERSITY (THE) |
发明人 |
MARSH, DAVID G. |
分类号 |
A61K39/35;(IPC1-7):61K39/35 |
主分类号 |
A61K39/35 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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