发明名称 |
IMMUNOMODULATORS AND ANTIVIRAL AGENTS |
摘要 |
<p>Compounds of the formula (Y)z where X is OH, NH2, SH, OR or SR (where R is alkyl of 1 to 4 carbon atoms or benzyl), R1 is H or alkyl of 1 to 8 carbon atoms, R2 is H or methyl, Y is the salt of an amine of the formula where R3 and R4 are lower alkyl, e.g., 1 to 4 carbon atoms and n is an integer of 2 to 4 with p-acetamidobenzoic acid and where z is a number from 0 to 10 are useful as immunomodulators, as antiviral agents and in specific cases have antitumor activity. The compounds and compositions where z is 1 to 10 are novel per se. When R2 is H the presence of Y enhances the immunoregulatory activity and the antiviral activity. If X is the NH2 there is immunoinhibitory activity but no immunostimulatory (immunopotentiatory) activity.</p> |
申请公布号 |
CA1122217(A) |
申请公布日期 |
1982.04.20 |
申请号 |
CA19790335702 |
申请日期 |
1979.09.14 |
申请人 |
NEWPORT PHARMACEUTICALS INTERNATIONAL, INC.;SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
SIMON, LIONEL N.;HADDEN, JOHN W. |
分类号 |
A61K31/13;A61K31/195;A61K31/52;A61K31/522;A61P31/12;A61P35/00;A61P37/02;A61P37/04;A61P37/06;C07C215/08;C07C233/54;C07D239/48;C07D473/00;C07D473/30;C07D473/34;C07D473/38;C07D473/40;(IPC1-7):C07D473/00 |
主分类号 |
A61K31/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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