LOW TEMPERATURE PREPARATION OF POLYMER MICROSPHERES

摘要

600-679 IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS Microspheres of core material and polymer are produced by adding a phase separation agent to a medium comprising a solution of the polymer and a solution or dispersion of the core material at a temperature of -40 to -100.degree.C. Preferably the core material is a drug and the polymer is biodegradable. The low temperature phase separation step prevents uncontrolled agglomeration of the microspheres.