| 摘要 |
NEW MATERIAL:The 2-(substituted phenyl)-5-alkylthiazolidin-4-one of formula I(R1 and R2 are 1-3C lower alkyl; n is 1-3). EXAMPLE:2-(2,3,4-Trimethoxyphenyl)-5-methylthiazolidin-4-one. USE:Remedy for peptic ulcer. It has no side effect, and has high safety, effectivity, and stability. It can be stored in open air at room temp. perfectly without change. PROCESS:The compound of formulaIis prepared by reacting the aromatic aldehyde of formula II with equimolar or slightly excess amount of thiolactic acid or its ester and a slightly excess amount, as ammonia, of an ammonium compound, pref. ammonium carbonate, etc., in an inert solvent such as benzene, at 50-150 deg.C.
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