| 摘要 |
NEW MATERIAL:The compound of formulaI, its ester or its salt. USE:Synthetic intermediate of pharmaceuticals having antimicrobial and beta-lactamase- inhibiting activities. PROCESS:The compound of formulaIis prepared by removing sulfuric acid from the compound of formula II or formula III in a weakly acidic (e.g. phosphoric acid, hydrochloric acid, etc.) to strongly basic (e.g. NaOH, Ba(OH)2, etc.) aqueous solution at 30-150 deg.C. The starting compound of formula II or formula III is KA- 6643-B substance having antimicrobial and beta-lactamase-inhibiting activies and can be separated from the cultivation product of Streptomyces sp. KC-6643 strain as the fermentation metabolite. Reduction of the compound of formulaIgives the compound of formula IV, which can be converted to the compound of formula V by reacting with ethanethiol. |
