| 摘要 |
<p>R2,R2'-15-hydroxy- prost-13-enoic acid and prostanoic acid derivs. and their lower alkyl esters and salts of formula (I) are new, (where R1 is H, lower alkyl, hydroxymethyl or -COOR; R is H or lower alkyl; R2 is H, lower alkyl or fluoro; R2' is fluoro, trifluoromethyl or lower alkyl and the dotted line between positions 13 and 14 indicates a double bond which is opt. hydrogenated. With the conditions that when R1 is H then R2' is trifluoromethyl and that when R2 is fluoro then R2' is lower alkyl or fluoro). Intermediates (IV) are also new (where R6 is lower alkyl, R1' is H, lower alkyl, hydroxymethyl, or -COOR6 and X is halo. With the condition that when R2 is fluoro then R2' is fluoro or lower alkyl).</p> |
