Penicillinverbindungen und Verfahren zu ihrer Herstellung

摘要

The invention relates to betaine penicillins of formula where Q+ is a quaternary ammonium group derived from a tertiary amine Q and X is a divalent organic radical. Typical betaines are a -trimethylaminobenzylpenicillin betaine, pyridinium methyl penicillin betaine and a -(pyridinoacetamido)benzyl penicillin betaine. The betaines are prepared by quaternizing, with a tertiary amine Q, a penicillin or non-toxic salt thereof, of formula where Q and X have the above meanings and R is the acid residue of a reactive ester, e.g. a halogen atom, a sulphuric acid residue, e.g. methoxy-sulphonyloxy or a sulphonic acid residue, e.g. toluene p-sulphonyloxy group. The tertiary amine is a trialkylamine, a heteroaromatic base or a reduced heteroaromatic base.