Process for the preparation of 1-(triarylalkyl)-4-phenylpiperidine derivatives

摘要

Compounds of the general formula I in which the substituents are defined in Claim 1, as well as their acid addition salts, are obtained by reacting a compound of the general formula II in which the substituents are defined in Claim 1, in the presence of an organic solvent with a suitable reducing agent to give compounds of the general formula III in which the substituents are defined in Claim 1, and subsequently treating resulting compounds of the general formula III in a suitable solvent with sodium hydride and then treating with an appropriate alkyl halide to form the required ether of the formula I, and converting resulting compounds of the general formula I where appropriate into their acid addition salts. The alkyl ethers of the formula I and their acid addition salts are effective antidiarrhoeal agents which have only a slight or even no analgesic effect.