| 摘要 |
PURPOSE:To obtain a drug for external use, containing kojic acid, having increased water solubility and included in maltosylcyclodextrin and having great melanization inhibitory effects. CONSTITUTION:The titled drug for external use containing kojic acid included in maltosylcyclodextrin. The above-mentioned included kojic acid is obtained by dispersing maltosylcyclodextrin in water, stirring the dispersion while slowly adding the kojic acid thereto and completely dissolving both. Since water solubility of the kojic acid is increased by the treatment, even 6% kojic acid can be blended in the drug for external use though the amount of the kojic acid which can be blended therein has hitherto been only 2.7%. Thereby a pharmaceutical having a wide range of change in content depending on the dosage form or symptoms is obtained. The amount of the blended maltosylcyclodextrin is preferably 1-5pts.wt. based on 1pt.wt. kojic acid. |
