| 摘要 |
<p>N-Carboxyalkyl dipeptides and derivatives thereof are disclosed which are useful as angiotensin converting enzyme inhibitors and as antihypertensives, and a process for preparing them. Those compounds are represented by the formula <CHEM> wherein R and R<5> are individually hydroxy, lower alkoxy, aralkoxy; R<1> is C1-8 alkyl; substituted C1-5 alkyl, substituted aralkyl or substituted heteroaralkyl; R<2> is hydroxy, amino, alkoxy, aralkyloxy; n is one, two or three; R<3> is aryl, heteroaryl, cycloalkyl, aminoloweralkyl, aralkyl; R<4> is hydrogen or loweralkyl; or R<3> and R<4> are joined to form a ring having the following formulae: <CHEM> R<6> is hydrogen or loweralkyl; p is 1, 2, or 3; W is a bond, -CH2-, or C=O; and, Z is a bond, -CH2-, or -CH2CH2-; and, the pharmaceutically acceptable salts thereof.</p> |
