4,5-Deoxymaytansinoids, their production and use.

摘要

This invention relates to 4,5-deoxymaytansinoid compounds represented by the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="36" wi="63" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein X is a hydrogen atom or an alkyl or acyl group, Y is a hydrogen or chlorine atom, and R is a hydrogen atom or a carboxylic acid-derived acyl group, and methods of producing the same. The compounds are useful as antitumor, antiprotozoal and antifungal agents.