| 摘要 |
The present invention relates to a novel process for producing pyrimidine nucleosides by a reaction between bis(tri-lower alkylstannyl)-5-halogenouracil and 2-substituted tetrahydrofurane. The novel process of the present invention makes it possible to obtain, depending upon the manner of substitution of tetrahydrofurane residue on two nitrogen atoms N1 and N3 of 5-halogenouracil, N1-mono-substituted compound, N3-mono-substituted compound and N1,N-di-substituted compound among which the last can be converted by hydrolysis thereof into N1-mono-substituted compound. The present invention further relates to novel N3-mono-substituted compounds and N1,N3-di-substituted compounds obtained by such process. The present invention still further relates to novel bis-(tri-lower alkylstannyl)-5-halogenouracil used in the present invention as a raw compound.
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