| 摘要 |
Title compds.(I; R = H, halogen, OH, alkyl, alkoxy, alkylthio, NH2, acylamino, alkylsulfonyl; alkylsulfonylamino; R1,R2,R3,R4 = H, alkyl; R5 = aryl, benzodioxanyl, aryloxy, arylthio; n = 0-3) and their acid addn. salts. useful as α- and β-adrenergic blocking agent and hypertensives were prepd. Thus, N-benzyl-1-methyl-3-phenylpropylamine and 5-bromoacetyl-2-methylbenzene sulfonamide were refluxed and brominated with excess boronhydride to give 5-[1-hydroxy-2-(N-benzyl-1-methyl-3-phenylpropylamino)ethyl -2-methylbenzene-sulfonamid, which was reduced catalytically over 10% Pd/C to give I(R = 4-Me; R1,R2,R3,R4 = H; R5 = C6H5).
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