| 摘要 |
Title compds.(I; R1,R2,R3 = H or lower alkyl; R4 = halogen; R = H or lower alkyl; X = halogen) were prepd. by reaction of II and halopyridine(III). Thus, 5.0g 5-bromoanthranillic acid reacted with 6.7g 2-chloro-5-methylpyridine and 67 mg potassium iodide at 145oC to give 3.57g 2-bromo-8-methyl-11-oxo-11H-pyrido[2,1-b quinazoline. I was one of the most active substances administered orally in the rat passive cutaneous anaphylasis test.
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