| 摘要 |
NEW MATERIAL:A compound of formulaI(Q is methylene, S; R<1> is H, alkyl, cycloalkyl, aralkyl, phenyl, pyridyl; each group may be substituted with lower alkyl, hydroxyl, mercapto, halogen or amino groups; A is straight or branched 1-3C alkylene). EXAMPLE:(3S,7S,13S,17S)-3,13-Dimethyl-1,15-dithia-1,11-diaza-2,6,12,16 -tetraoxotricyclo[15,3,0,0<7>,<11>]eicosane. USE:Hypotensor: since lipo-philic properties are increased, the absorbability is improved and effective time is prolonged. PREPARATION:The reaction of a compound of formula II is conducted in a solvent such as dichloromethane or chloroform in the presence of a dehydrating agent such as a carbodimide or phosphorus oxychloride in an atmosphere of an inert gas such as nitrogen or argon to give the compound of formulaI. |
