| 摘要 |
NEW MATERIAL:A carbostyril derivative of formula I [R<1> is H, lower alkyl, phenyl(lower alkyl), lower alkenyl, etc.; R<2> is halogen, lower alkyl, lower alkoxy, carboxy, OH, amino, etc.; n is 0 or 1-3; A is C=0 or CHOH; B is lower alkylene] and its salt. EXAMPLE:6-[1-Oxo-4-(4-phenylpiperazinyl)butyl]-3,4-dihydrocarbostyril. USE:Central nervous system depressand and antihistaminic agent. For example, it is useful as a central nervous system relaxant, hypnotic, preoperative agent, antischizophrenic agent, etc. having low side effects. PROCESS:The compound of formula I is prepared by reacting a carbostyril derivative of formula II (X is halogen, etc.) with a piperazine derivative of formula III. |
