NOVEL TETRAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND ANTI-ULCER COMPOSITION CONTAINING THE SAME

摘要

Tetrazole derivatives of the formula I where R1 denotes hydrogen, lower alkyl, cycloalkyl or phenyl, A denotes sulphur or lower alkylenethio, 2 is 0 or 1, B denotes lower alkylene, and R2 denotes hydroxyl, lower alkoxy or a group where R3 or R4 are identical or different and each denotes hydrogen, lower alkyl, cycloalkyl, phenyl, cycloalkyl-lower alkyl, phenyl-lower alkyl, hydroxyl- lower alkyl, a saturated or unsaturated heterocyclic group containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulphur or lower alkyl which is substituted by such a saturated or unsaturated heterocyclic group, or R3 and R4 can, together with the nitrogen atom to which they are bonded, with or without interruption by oxygen or nitrogen, form a saturated or unsaturated heterocyclic group which can be substituted by lower alkyl or lower alkanoyl; with it being possible for cycloalkyl, phenyl or phenyl-lower alkyl on the cycloalkyl or phenyl ring to have one or two substituents selected from the group consisting of lower alkoxy, lower alkyl, halogen, N,N-di-lower alkylamino, nitro, aminosulphonyl, hydroxyl or lower alkanoyloxy, or pharmaceutically tolerable salts thereof, are prepared by a number of different processes, inter alia by way of the previously unknown corresponding compounds II the tetrazole derivatives I have a prophylactic and therapeutic effect on peptic and/or duodenal ulcers and also possess anti-inflammatory activity.