发明名称 |
2-Carbamoyloxymethyl-penicillin derivatives |
摘要 |
Penicillin sulfoxide esters are reacted with an isocyanate to produce the corresponding (substituted)-2-carbamoyloxymethylpenam, the corresponding (substituted)-3-carbamoyloxycepham or the corresponding 3-methylcephem. The 6- or 7-side-chain of these products may be cleaved to give the corresponding 6-amino (penams) or 7-amino (cephams and cephems) compounds, and the latter may be reacylated to produce different 6-acyl-2-carbamoyloxymethyl penams, 7-acyl-3-carbamoyloxy cephams and 7-acyl-3-methylcephems. The substituent groups may be removed from the (substituted)-2-carbamoyloxypenams or the (substituted)-3-carbamoyloxycephams to give the corresponding free 2-carbamoyloxymethylpenams or 3-carbamoyloxycephams, respectively.
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申请公布号 |
US4322347(A) |
申请公布日期 |
1982.03.30 |
申请号 |
US19780893092 |
申请日期 |
1978.04.03 |
申请人 |
BRISTOL-MYERS COMPANY |
发明人 |
CUNDALL, ROBERT L.;WALKER, DEREK |
分类号 |
A61K31/43;A61K31/545;A61K31/546;A61P31/04;C07D499/00;C07D499/21;C07D499/42;C07D499/44;C07D499/46;C07D499/60;C07D499/64;C07D499/68;C07D499/74;C07D499/76;C07D499/78;C07D499/80;C07D501/14;C07D501/18;C07D501/22;C07D501/59;C07D519/06;(IPC1-7):C07D499/32;A61K31/38 |
主分类号 |
A61K31/43 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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