VACCIN CONTRE LA VARICELLE

摘要

1293310 Varicella vaccine MERCK & CO Inc 26 April 1971 [28 April 1970] 11385/71 Heading A5B A process for the preparation of a live varicella virus useful as an antigen in a vaccine that will evoke in man an antibody response against a virulent varicella virus without causing the severe clinical manifestations of the disease, comprises serially passaging the virulent virus at 30-34‹C in a tissue culture preparation comprising human diploid cell strains or primary cells of simian origin a sufficient number of times to attenuate the virus. The tissue culture preparation is suitably human foetal lung tissue or monkey testicular tissue.