| 摘要 |
PURPOSE:To obtain the titled compound useful as a pharmaceutical or its synthetic intermediate with simple process, in high yield in large quantity, by reacting a 1-adamantanecarboxylic acid halide with olefins. CONSTITUTION:A 1-adamantanecarboxylic acid halide of formula I (X is halogen) is made to react with olefins of formula CH2=CH-R (R is 1-20C alkyl, alkoxycarbonyl having 1-10C alkoxy, etc.) in the presence of a palladium catalyst (e.g. palladium acetate) and tertiary amines (e.g. pyridine) to obtain the objective compound of formula II. The reaction is carried out in a solvent (e.g. xylene) or in the absence of solvent at 0-200 deg.C, preferably 100-150 deg.C. The amounts of olefins and catalyst are 1-10 equivalent and 0.01-20mol.% based on the compound of formula I, respectively. |
