| 摘要 |
PURPOSE:To collect the titled antibiotic from a culture, by cultivating a microorganism, belonging to the genus Dactylosporangium, and capable of producing the titled antibiotic. CONSTITUTION:A species of the genus Dactylosporangium, e.g. Dactylosporangium vinaceum SF-2127 (FERM-P No. 5610) or Dactylosporangium matsuzakiense, is cultivated in an ordinary culture medium containing a carbon source, e.g. glucose, starch syrup or starch, a nitrogen source, e.g. soybean flour, peptone or meat extract, and an inorganic salt, under aerobic conditions, and the resultant dactimicin produced and accumulated in the culture fluid is then isolated. After the removal of the microbial cells, the isolation and purification steps are carried out by the chromatography with a cation exchange resin, desalination etc. to give the aimed dactimicin of high purity. |
