PROCESS FOR PREPARING OXIM DERIVATIVES 3-ACETOXY METHYL 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID

摘要

Title compds. [I;R1 = -CO2R1'(R1' = C1-3alkyl, H, alkali metal, organic amine), NO2, -CO2NH2; R2,R3 = H, C1-3 alkyl; A = H, alkali metal, organic amino salt were prepd. Thus, ClCH2COC(:NOH)CO2Et was treated with thiourea to give the thiazole II, which was N-tritylated, hydrolyzed with acid, and treated with BrCH2CO2Et to give III. 7-Aminocephalosporanic acid was treated with III, followed by detritylation to give I(R1 = CO2Et; R2,R3 = H).