Chiral supports for resolution of racemates

摘要

Material which can be utilized as the stationary phase in liquid-solid chromatography for the resolution of racemic mixtures comprises an inorganic oxide silylated with a reagent whose remaining terminus is covalently bonded to a chiral hydroxy acid. For example, a 3-aminopropylsilylated silica gel may be reacted with a chiral tartaric anhydride to form a carboxamide linkage by which the chiral acid is covalently bound to the support.