| 摘要 |
Title compds. V(X = O; Y = esterified or aminated carboxyl; CN; R1-ii = etherified hydroxy or mercapto, amino; R2 and R3 are lower alkyl or I), useful as antivirus agents were prepd. by the reaction of IV(R1-iii = OH) and RiiH. Thus, 15.04 g methyl-1,2,3,4-tetrahydro-2,4-dioxypyrimidine-5-carboxylate monohydrate were suspended, followed by addition of 15.6 g calcium carbonate and 5.2 g sodium hydrogen sulfite to give 13.0 g methyl-5-fluoro-6-hydroxy-1,2,3,4,5,6-hexahydro-2,4-dioxopyrimidine-5-carboxylate.
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