| 摘要 |
Auranofin(I; Ac = acetyl; Y = Bromo, Chloro, tosyloxy, trifluoromethane sulfonyloxy or mesyloxy), useful for treatment of arthritis, was prepd. by reacting compd.(II) with Na2S(or K2S) and XAuP(C2H5)3 (X = halogen). Thus, 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide 2.0 g was dissolved in water 20 ml and chloroform 20 ml. The soln. and ClAuP(C2H5)3 1.7 g was added in water 20 ml soln. of Na2SH2O 1.2 g, stirred at room temp. for 1 hr and then chloroform layer was separated. The chloroform layer was washed, dried, filtered, evaporated, and then recrystallized to give auranofin (m.p. 99-102≦̸C).
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