| 摘要 |
Title compds. (I; A = -N=C(R1)-(R1=H, C1-3 alkyl), R2 = C1-3 alkoxy; R3 = C1-3 alkoxy, forming methylenedioxy or ethylenedioxy with R2; R4,R5 = H, C1-3 alkyl; R6 = H, C1-3 alkoxy; R7 = C1-3 alkoxy, forming methylenedioxy or ethylenedioxy; n = 2-3) useful as heart frequency decreasing and hypotensive agent, were prepd. by reaction of II and III(Z = Cl, Br, I, alkylsulfonyloxy, arylsulfonyloxy). Thus, 0.5 g NaH was added to 3.0 g II(A = -N=C(CH3)-; R2,R3 = CH3O) in 100 ml dimethyleneformamide and heated at 30≦̸C, 30min. The heated mixt. was added to 8.5 g III(R4 = CH3; R5 = H; R6,R7 = CH3O; Z = Br, n= 3) and heated at 140≦̸C, 8 hr to give 0.6 g IHCl.
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