| 摘要 |
NEW MATERIAL:A cyanoguanidine derivative shown by the formula I [A is (substituted) phenyl, furyl, thienyl, etc.; B is pyridyl, phenyl, etc.; R is lower alkyl, lower alkenyl, group shown by the formula IV (R1 and R2 are lower alkyl, both and a linked N form N-containing heterocyclic ring; n is 1-3), group shown by the formula V (R3 is lower alkyl; m is 4 or 5); X is alkylene, etc.; p is 0 or 1; when p=0 and A is unsubstituted phenyl, B is phenyl, etc.] and its acid addition salt. EXAMPLE:N-Cyano-N'-methyl-N''-[alpha-(2-pyridyl)orthomethylbenzyl]guan idine. USE:An anti-ulcer, antidepressant, anti-inflammatory agent, etc.; having no side effects resulting from anticholinergic actions. PROCESS:A compound shown by the formula II (Y is lower alkoxy, lower alkylthio) is reacated with a compound shown by the formula III to give a compound shown by the formula I. |
