摘要 |
7β-acylamidoceph-3-em-4-carboxylic acids and 6β-acylamidopenam-3-carboxylic acid, and their alk. salts or acid salts, esters and sulfoxides with antibacterial activity and high stability to β-lactamase, were synthesized. 7-aminoceph-3-em-4-carboxylic acid or 6-aminopenam-3-carboxylic acid was related with acylating agent at -20-20≦̸C in the inactive inog. solvent to give syn- or anti- isomer, or the mixt. contg. more than 75% one isomer. |