摘要 |
1329812 Sulphonyl-semicarbazides SCIENCE UNION ET CIE SOC FRANCAISE DE RECHERCHE MEDICALE 2 Feb 1972 [15 Feb 1971] 4638/71 Heading C2C Novel compounds (I) (including salts thereof) where Het signifies indolinyl, isoindolinyl, hexahydroindolinyl, 4,7-endoalkylene-tetra- or -hexahydroisoindolinyl, 4,7-endoxo-hexahydroisoindolinyl, tetra- or deca-hydroquinolyl or -hydroisoquinolyl, aza-bicyclo[3,10]hexyl, aza-bicyclo- [3,2,0]heptyl, aza - bicyclo[3,3,0]octyl, azabicyclo[2,2,2]octyl, aza - bicyclo[3,2,1]octyl, aza-bicyclo[4,3,0]-nonyl or -nonenyl, azabicyclo[3,2,2]nonyl or aza-bicyclo[3,3,1]nonyl bonded via their nitrogen atom, are made by reacting KO 2 C.C 6 H 4 .SO 2 .NHK with Het- NH.CO.NPh 2 and, if desired, acidifying the product obtained. Pharmaceutical preparations especially showing microcirculation-improving, fibrinolytic- and platelet-adhesiveness and aggregation-decreasing properties contain (I) as active ingredient. Administration may be orally, rectally or parenterally. |