PROCESS FOR PREPARING NITRO COMPOUNDS

摘要

This invention concerns compounds showing activity as histamine H2-receptor antagonists. The compounds of the invention are of Structure where Het is a substituted or unsubstituted, fully-unsaturated 5- or 6- membered heterocycle containing at least one nitrogen atom, or a furan or thiophene ring substituded by a substituted or unsubstituted aminoalkyl group; Z is sulphur, methylene or oxygen; m is 0, 1 or 2, 3 is 2 or 3 with m + n being 3 or 4; and B is a substituted or unsubstituted alkanediyl group or a 2-substituted-2-aza-l,3-propanediyl group and acid addition salts thereof. The compounds of he invention can be prepared by reacting a compound of formula Het (CH2)mZ(CH2)nNH2 or Het(CH2)mY (where Y is a group displaceable by a mercaptan) with an appropriate 2-substituted-3-nitro-heterocycle. The compositions of the invention contain at least one compound of the inventicn and a pharmaceutical carrier.