| 摘要 |
Title compds. [I; R1, R2, R3 = H, lower alkyl, lower alkoxy, lower alkylthio, halogen, cyclopropyl, cyclobutyl, hydroxy; R4 = (a), (b); Y = H, methyl; n = 0,1; R5,R6 = H, lower alkyl , having antiallergy activities, were prepd. by aminolysis of compd. (II) with amino compd. (III). Thus, 2-methoxy-11-oxo-11H-pyrido[2,1-b quinazoline-8-carboxylic acid 6.0 g was dissolved in thionyl chloride 100 ml and refluxed for 3 hr. The reactant was dried and suspended in anhydrous tetrahydrofuran 200 ml. Diethylamine was passed through the mixt. until yellow discolored to yellowish green and then dried. The residue was recrystallized with ethylacetate 500 ml to give compd. (I) 4.0 g.
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