发明名称 |
Cephalosporin intermediates |
摘要 |
In the preferred embodiment of the present invention trimethylsilyl 7-trimethylsilyloxycarbonylaminodecephalosporanate was prepared by bubbling dry carbon dioxide into an anhydrous solution of trimethylsilyl 6-trimethylsilylaminodecephalosporanate and found to be a useful intermediate in the production of cefadroxil and cephalexin by its acylation in anhydrous media with the appropriate 2-phenylglycyl chloride hydrochloride. Other cephalosporins are produced by acylation of 7-trimethylsilyloxycarbonylaminoceph-3-em-4-carboxylic acids or esters having a variety of substituents at the 3-position.
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申请公布号 |
US4316017(A) |
申请公布日期 |
1982.02.16 |
申请号 |
US19800158546 |
申请日期 |
1980.06.11 |
申请人 |
BRISTOL-MYERS COMPANY |
发明人 |
WALKER, DEREK;SILVESTRI, HERBERT H.;SAPINO, CHESTER;JOHNSON, DAVID A. |
分类号 |
C07D501/06;C07D501/36;C07F7/10;(IPC1-7):C07D501/36 |
主分类号 |
C07D501/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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